Natasha Lyonne, the talented American actress, does not have any children as of my knowledge. She has been quite private about her personal life, so there is no public information available regarding her having children. Natasha Lyonne has had a successful career in the entertainment industry, starring in various films and TV shows, and has garnered a significant fanbase. However, it is important to note that personal details about celebrities can sometimes change or be kept private, so it is always best to refer to the latest information available.